-
Granzymes are
serine proteases released by
cytoplasmic granules within cytotoxic T
cells and
natural killer (NK) cells. They
induce programmed cell death...
-
Granzyme B (GrB) is one of the
serine protease granzymes most
commonly found in the
granules of
natural killer cells (NK cells) and
cytotoxic T cells....
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Granzyme A (GzmA, EC 3.4.21.78, CTLA3, HuTPS, T-cell ****ociated
protease 1,
cytotoxic T
lymphocyte serine protease, TSP-1, T-cell
derived serine proteinase)...
-
Granzyme B is a
serine protease that in
humans is
encoded by the GZMB gene.
Granzyme B is
expressed by
cytotoxic T
lymphocytes (CTL) and
natural killer...
-
Granzyme K (GrK) is a
protein that is
encoded by the GZMK gene on
chromosome 5 in humans.
Granzymes are a
family of
serine proteases which have various...
-
collectively termed granzymes and
include 4
distinct gene products:
granzyme A,
granzyme B,
granzyme H, and Met-ase, also
known as
granzyme M. GRCh38: Ensembl...
-
Granzyme H is a
protein that in
humans is
encoded by the GZMH gene. GRCh38:
Ensembl release 89: ENSG00000100450 – Ensembl, May 2017 GRCm38:
Ensembl release...
-
increases cytotoxic activity by
increasing the
expression of perforin,
granzyme B, Fas ligand, and TNF. In T cells, the
activation of the JNK
pathway by...
- (IP-10, lymphotactin),
trigger cytolysis of
target cells (perforins,
granzymes...), and
interact with
other cells, such as
epithelial cells, monocytes...
- p****ive
diffusion of a
family of pro-apoptotic proteases,
known as the
granzymes, into the
target cell. The
lytic membrane-inserting part of
perforin is...
