- 3'-hydroxymethyl- and 3'-carboxy-metabolites (middle and bottom, respectively). The
carboxy groups at the
bottom right of each
substance can be
glucuronidized....
-
levels of
unconjugated bilirubin in adults. However,
other substances glucuronidized by the
affected enzymes in
those with Gilbert's
syndrome could theoretically...
- • middle: carbamazepine-10,11-epoxide, the
active metabolite • bottom: carbamazepine-10,11-diol, an
inactive metabolite,
which is then
glucuronidized...
- the
active substance,
thereby inactivating it. Besides, ACT-333679 is
glucuronidized by the
enzymes UGT1A3 and UGT2B7. The
terminal half-life of selexipag...
- One of
several metabolism pathways involving the
oxidizing enzyme CYP3A4 (and CYP3A5) and the
glucuronidizing enzyme UGT1A1....
- with a
biological half-life of 0.7 hours. 40–60% are
excreted in the
glucuronidized form.
Ferric maltol was
approved for
medical use in the
European Union...
-
sixth hour, and
lasts for
nearly 24 hours. One
third of the dose is
glucuronidized, the rest is
excreted directly through the
kidney (1/3) and the faeces...
-
small extent by CYP2D6 and CYP2C19. It is also reduced,
hydrolyzed and
glucuronidized by
unspecified enzymes. All
metabolites seem to be inactive. Biological...
-
mainly metabolized in the
liver by
oxidative metabolism of CYP3A4, and
glucuronidized by UGT1A9.
Their half life
ranges from 20 to 48 hours. Most of the administered...
