- The
globins are a
superfamily of heme-containing
globular proteins,
involved in
binding and/or
transporting oxygen.
These proteins all
incorporate the...
- beta (beta
globin, β-
globin,
haemoglobin beta,
hemoglobin beta) is a
globin protein,
coded for by the HBB gene,
which along with
alpha globin (HBA), makes...
-
important regulatory molecule nitric oxide bound to a
thiol group in the
globin protein,
releasing it at the same time as oxygen.
Hemoglobin is also found...
- of two ζ
globins (zeta
globins) and two ε
globins (epsilon
globins) (ζ2ε2) Hb Gower-2,
composed of two
alpha globins and two
epsilon globins (α2ε2) Hb...
-
underproduction of HbA (adult hemoglobin). The
imbalance of
alpha to beta
globin chains leads to
ineffective erythropoiesis,
increased hemolysis, and deranged...
-
common adult form of
hemoglobin and is
composed of two
alpha and two delta-
globin subunits. This
hemoglobin makes up 1-3% of
hemoglobin in adults. Hemoglobin...
- The
human β-
globin locus is
composed of five
genes located on a
short region of
chromosome 11,
responsible for the
creation of the beta
parts (roughly...
-
Hematopoietic Stem
Cells Transduced Ex Vivo with a
Lentiviral βΑ-T87Q -
Globin Vector (Lenti
Globin BB305 Drug Product)". Blood. 124 (21): 549. doi:10.1182/blood...
-
manner and is tissue-specific, as seen in the
selective expression of β-
globin genes in
erythroid cells.
Expression levels of
genes can be
modified by...
-
hemoglobin protein that in
humans is
encoded by the HBA1 gene. The
human alpha globin gene
cluster located on
chromosome 16
spans about 30 kb and
includes seven...
