-
Geldanamycin is a 1,4-benzoquinone
ansamycin antitumor antibiotic that
inhibits the
function of Hsp90 (Heat
Shock Protein 90) by
binding to the unusual...
- a
variety of cancers. Hsp90
inhibitors include the
natural products geldanamycin,
Retaspimycin hydrochloride (IPI 504, a
hydroquinone hydrochloride salt...
-
azithromycin The
antihelminthics ivermectin Ansamycins The
antitumor agents geldanamycin and macbecin, The
antibiotic rifamycin Polyenes The
antifungals amphotericin...
- (17-N-allylamino-17-demethoxygeldanamycin, 17-AAG) is a
derivative of the
antibiotic geldanamycin that is
being studied in the
treatment of cancer,
specifically in younger...
- MutL) superfamily. A
common binding pocket for ATP and the
inhibitor geldanamycin is
situated in the N-terminal domain.
Amino acids that are
directly involved...
- Beaulieu,
Carole (4
March 2017). "Streptomyces
cameroonensis sp. nov., a
Geldanamycin Producer That
Promotes Theobroma cacao Growth".
Microbes and Environments...
-
Another variation consists of
benzene or a
benzoquinone ring
system as in
geldanamycin or ansamitocin.
Ansamycins were
first discovered in 1959 by
Sensi et...
-
Nguyen P,
Trepel J,
Garcia de
Herreros A, et al. (February 2001). "
Geldanamycin abrogates ErbB2 ****ociation with proteasome-resistant beta-catenin in...
-
chemical compound which is a semi-synthetic
derivative of the
antibiotic geldanamycin. It is
being studied for the
possibility of
treating cancer. WO application...
- it is
obtained as a byproduct, or contaminant, at the
fermentation of
geldanamycin. It is also
called polyetherin A,
azalomycin M,
helixin C, antibiotic...
