-
Gasdermin D (GSDMD, from
combination of
gastro and dermato,
referencing the
locations where its
family of
proteins were
originally found to be primarily...
- pro-inflammatory
cytokines IL-1β and IL-18, as well as the pore-forming
protein gasdermin D.
Formation of
pores causes cell
membrane rupture and
release of cytokines...
-
Gasdermin A is a
protein that in
humans is
encoded by the
GSDMA gene. GRCh38:
Ensembl release 89: ENSG00000167914 – Ensembl, May 2017 GRCm38: Ensembl...
-
cytokines interleukin 1β and
interleukin 18 as well as the
pyroptosis inducer Gasdermin D, into
active mature peptides. It
plays a
central role in cell immunity...
- caspase-11 in mice, and caspases-1, -4, and -5 in humans, and is
executed by
gasdermin D. In contrast,
necroptosis occurs via RIPK1/3-mediated MLKL activation...
-
Gasdermin B is a
protein that in
humans is
encoded by the
GSDMB gene. This gene
encodes a
member of the
gasdermin-domain
containing protein family. Other...
- activation. A
crucial downstream substrate for
pyroptotic caspases is
Gasdermin D (GSDMD)
Inflammation is a
protective attempt by an
organism to restore...
-
Gasdermin C is a
protein that in
humans is
encoded by the
GSDMC gene. GRCm38:
Ensembl release 89: ENSMUSG00000056293 – Ensembl, May 2017 "Human PubMed...
-
Myddosome and IKK-beta in Toll-like
receptor signaling, the Inflammasome,
gasdermins, and the
synaptic recombination-activating gene (RAG) complexes. Based...
- inflammasome-mediated
pyroptosis through oxidation of the pore
forming protein gasdermin D. Kagan's work with Dr.
Randi Rotjan explored the
limits of
innate immune...
