-
vertebrates and
comprises six
members in humans, GSDMA, GSDMB, GSDMC, GSDMD,
GSDME (DFNA5) and DFNB59 (Pejvakin).
Members of the
gasdermin family are expressed...
-
apoptotic cells are not
scavenged by macrophages,
GSDME expression is then
upregulated by p53.
GSDME is then
activated by caspase-3 to form
pores on the...
-
GSDME Identifiers Aliases GSDME, ICERE-1, DFNA5, DFNA5,
deafness ****ociated
tumor suppressor,
gasdermin E
External IDs OMIM: 608798; MGI: 1889850; HomoloGene:...
- HGNC:23690 Q8TAX9 6681
GSDMC HGNC:7151 Q9BYG8 6682
GSDMD HGNC:25697 P57764 6683
GSDME HGNC:2810 O60443 6684 GSE1 HGNC:28979 Q14687 6685 GSG1 HGNC:19716 Q2KHT4...
- is
sensed as a
virulence strategy by the host,
leading to
gasdermin E (
GSDME)-dependent
pyroptosis and
release of IL-1α. The BCL-2
family members MCL-1...
