-
Transmembrane glycoprotein NMB is a
protein that in
humans is
encoded by the
GPNMB gene. Two
transcript variants encoding 560 and 572
amino acid
isoforms have...
-
glycoprotein NMB (
GPNMB). In May 2010, the U.S FDA
granted Fast
Track designation to CDX-011 for the
treatment of advanced, refractory, or
resistant GPNMB-expressing...
-
conjugate known as
glembatumumab vedotin (CDX-011),
which targets the
protein GPNMB, has also
shown encouraging clinical trial results in 2009. PARP inhibitors...
- acidity,
leading to cell death. Yes Anti-
GPNMB vaccine Glycoprotein nonmetastatic melanoma protein B (
GPNMB). A
protein that
enrich senescent cells studied...
-
Brentuximab (cAC10), 3–5
units of MMAE per
molecule targeting the
glycoprotein GPNMB which is
found in
aggressive melanoma, glioma,
breast cancer and
other tumours:...
- (CA-IX)
clear cell
renal cell
carcinoma Glembatumumab vedotin mab
human GPNMB melanoma,
breast cancer Glofitamab Columvi BsAb
humanized CD20, CD3 Y diffuse...
-
protect the cell from
extreme environments, and in the
human receptor SorCS2.
GPNMB; PKD1; PKD1L1; PMEL; SORCS1; SORCS2; SORCS3
Bycroft M,
Bateman A, Clarke...
- were
found to have
elevated expression of
transmembrane glycoprotein NMB (
GPNMB), a
transcriptional target of TFE3. Subsequently, FLCN was
shown to regulate...
- HGNC:17030 Q9HCN4 6497 GPN2 HGNC:25513 Q9H9Y4 6498 GPN3 HGNC:30186 Q9UHW5 6499
GPNMB HGNC:4462 Q14956 6500 GPR3 HGNC:4484 P46089 6501 GPR4 HGNC:4497 P46093 6502...
-
phosphorylation of p38 and MITF with
subsequently increased expression of
GPNMB.
Reduced sulfate availability due to
impaired activity of ARSB has been...
