- In
biochemistry and medicine,
glycoprotein IIb/IIIa (
GPIIb/IIIa, also
known as
integrin αIIbβ3) is an
integrin complex found on platelets. It is a transmembrane...
- ITGA2B
Identifiers Aliases ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B,
GPIIb, GT, GTA, HPA3, PPP1R93,
integrin subunit alpha 2b, GT1
External IDs OMIM:...
- the
platelets contain defective or low
levels of
glycoprotein IIb/IIIa (
GpIIb/IIIa),
which is a
receptor for fibrinogen. As a result, no
fibrinogen bridging...
-
glycoprotein IIb/IIIa inhibitors, also
GpIIb/IIIa inhibitors, is a
class of
antiplatelet agents.
Several GpIIb/IIIa
inhibitors exist:
abciximab (abcixifiban)...
-
either end
capable of
binding GPIIb/IIIa,
activated platelets with
exposed GPIIb/IIIa can bind
fibrinogen to aggregate.
GPIIb/IIIa may also
further anchor...
- in the
glycoprotein IIb/IIIa (
GPIIb/IIIa) receptor,
giving it high
affinity for fibrinogen.
Binding of
fibrinogen to
GPIIb/IIIa
receptors leads to platelet-to-platelet...
-
inhibits an RSV
fusion (F)
protein humanized abciximab prevent coagulation in
coronary angioplasty inhibits the
receptor GpIIb/IIIa on
platelets chimeric...
-
changes within the GPIb-V-IX complex. In consequence, this
complex activates GPIIb / IIIa
membrane glycoproteins,
allowing them to bind fibrinogen. Fibrinogen...
- to them. Low-resolution
images of
detergent extracts of
intact integrin GPIIbIIIa,
obtained using electron microscopy, and even data from
indirect techniques...
-
actin monomers. Heptinstall, J. A. May H.
Ratan J. R.
Glenn W. L (1998). "
GPIIb-IIIa
antagonists cause rapid disaggregation of
platelets pre-treated with...
