-
hexanucleotide repeat expansion of the six
letter string of
nucleotides GGGGCC. In
approximately half of all alleles, the
hexanucleotide repeat is repeated...
-
development of FTD and ALS.
These two
diseases have a
causal relationship to
GGGGCC (G4C2)
repeats within the 1st
intron of C9orf72 gene.
Normal individuals...
- TGGAA, TTTTA, TTTCA, and AAGGG),
three hexanucleotide (GGCCTG, CCCTCT, and
GGGGCC), and one
dodecanucleotide (CCCCGCCCCGCG)
repeat cause 13
other diseases...
-
Neuron in mid-2011,
showing that a
hexanucleotide repeat expansion of the
GGGGCC genetic sequence within an
intron of this gene was responsible. This expansion...
-
lateral sclerosis and
frontotemporal dementia are
caused by
hexanucleotide GGGGCC repeat sequences in the C9orf72 gene,
causing RNA
toxicity that
leads to...
- M,
Miller BL, Wong PC,
Petrucelli L, Kim HJ, Gao FB,
Taylor JP (2015). "
GGGGCC repeat expansion in C9orf72
compromises nucleocytoplasmic transport". Nature...
-
amyotrophic lateral sclerosis (ALS) have been
found to
develop from the
repeated GGGGCC sequence transcribed from an
intron in the C90RF72 gene.
These toxic RNA...
-
Miller BL, ****son DW,
Boylan KB, Graff-Radford NR,
Rademakers R:
Expanded GGGGCC Hexanucleotide Repeat in
Noncoding Region of C9ORF72
Causes Chromosome 9p-Linked...
- Cruts, M.; Van Broeckhoven, C.; Ha****, C.; Edbauer, D. (2013). "The C9orf72
GGGGCC Repeat Is
Translated into
Aggregating Dipeptide-Repeat
Proteins in FTLD/ALS"...
-
Porphyrin Distorts RNA G-quadruplex
Structures of the Disease-****ociated r(
GGGGCC)n
Repeat of theC9orf72Gene and
Blocks Interaction of RNA-binding Proteins"...
