- The
GABAA receptor (
GABAAR) is an
ionotropic receptor and ligand-gated ion channel. Its
endogenous ligand is γ-aminobutyric acid (GABA), the
major inhibitory...
-
receptors (
GABAAR). A
structural isomer of chloralose, β-chloralose (also
called parachloralose in
older literature), is
inactive as a
GABAAR modulator...
- In pharmacology,
GABAA receptor positive allosteric modulators, also
known as
GABAkines or
GABAA receptor potentiators, are
positive allosteric modulator...
- Nonetheless, the
GABAAR gamma subunit is
palmitoylated and the
alpha subunit binds to PIP2. When the
agonist GABA
binds to
GABAAR it
causes a translocation...
- JR (April 2020). "Subtype
Selective γ-Aminobutyric Acid Type A
Receptor (
GABAAR)
Modulators Acting at the
Benzodiazepine Binding Site: An Update". Journal...
- Abrepota, Bakeja,
Bharchoondh Bahawalani, Damro, Damhio, Dandio, Detho, Gābar,
Gābaar, Gābhar, Gābrio, Gaad, Gohata, Gandhai, Husrani, Tayuja, Tar'ra, Tanak,...
- (2009). "Activity-dependent
tuning of
inhibitory neurotransmission based on
GABAAR diffusion dynamics". Neuron. 62 (5): 670–82. doi:10.1016/j.neuron.2009.04...
- S, Wang J,
Huang S, Wang Y, Ma Y (3
February 2024). "The
Activation of
GABAAR Alleviated Cerebral Ischemic Injury via the
Suppression of
Oxidative Stress...
-
Aguayo LG (2016). "Potentiation of
Gamma Aminobutyric Acid
Receptors (
GABAAR) by Ethanol: How Are
Inhibitory Receptors Affected?".
Frontiers in Cellular...
-
Carisoprodol allosterically modulates and
directly activates the
human α1β2γ2
GABAAR (GABAA) in the
central nervous system,
similar to barbiturates. This causes...
