-
disease caused by a
deficiency in
multiple sulfatase enzymes, or in
formylglycine-generating enzyme,
which activates sulfatases.: 502 It is
similar to...
-
Formylglycine-generating
enzyme (FGE),
located at 3p26.1 in humans, is the name for an
enzyme present in the
endoplasmic reticulum that
catalyzes the...
-
introduced into
fusion proteins, and by
subsequent treatment with the
formylglycine-generating
enzyme (FGE), the
cysteine of the tag is
converted to a reactive...
- such as glycosaminoglycans, sulfolipids, and
steroid sulfates. C-alpha-
formylglycine (FGly), the
catalytic residue in the
active site of
eukaryotic sulfatases...
-
before or
after the
formation of the
amide bond. In the
latter case,
formylglycine would be an
intermediate in
hadacidin biosynthesis. N-Hydroxylation...
-
sulfatases are only
active if they
contain a
unique amino acid, C-alpha-
formylglycine (FGly). The FGly
residue is
posttranslationally generated from a cysteine...
-
Squire J. (July 2008). "In
Vitro Characterization of AtsB, a
Radical SAM
Formylglycine-Generating
Enzyme That
Contains Three [4Fe-4S] Clusters†". Biochemistry...
- the
enzyme active site:
formylglycine (FGly70), two
histidines (His125 and His181), and
aspartic acid (Asp273). The
formylglycine residue (FGly70) is first...
-
mutating the
catalytically active cysteines to alanine,
thereby blocking N-
formylglycine formation, they
found QSulf1 was
responsible for
Wingless (Wnt) release...
- is
thought that such
compounds irreversibly modify the
active site
formylglycine residue of
steroid sulfatase. Steryl-sulfatase is also
known as arylsulfatase...
