- In
molecular biology,
foldases are a
particular kind of
molecular chaperones that ****ist the non-covalent
folding of
proteins in an ATP-dependent manner...
-
refolding them. They
stand in
opposition to
foldases,
which are
chaperones that use ATP to fold proteins.
Foldase Chaperonin Co-chaperone Hoffmann, J. R....
-
cytosol of eukaryotes, and in mitochondria. Some
chaperone systems work as
foldases: they
support the
folding of
proteins in an ATP-dependent
manner (for example...
-
initiation of the UPR. BiP can
actively fold its
substrates (acting as a
foldase) or
simply bind and
restrict a
substrate from
folding or
aggregating (acting...
- to the
multiple myeloma treatment bortezomib (Btz) by
impacting BiP's
foldase and
ATPase activities. In
another collaborative study published in Scientific...
- PMID 13683522. Kris
Pauwels and
other (2007). "Chaperoning Anfinsen:The
Steric Foldases" (PDF).
Molecular Microbiology. 64 (4): 917–922. doi:10.1111/j.1365-2958...
-
substrate protein (step 3).
Protein disulfide isomerase (PDI), a
resident foldase of the
endoplasmic reticulum, is a multi-functional
protein that catalyses...
-
proteins such as P3H1, CRTAP, BiP, GRP94, PDI, and
calreticulin to form
foldase and
chaperone complexes and
facilitate protein folding,
especially for...
- a rate
limiting step in
protein folding. PrsA
homologs also
contain a
foldase domain suspected to aid in the
folding of
proteins but,
unlike the parvulin...
-
demonstrated that the apo
state of the
chaperonin GroEL possesses intrinsic foldase/unfoldase activities."
Clore pla**** a
pivotal role in the
development of...
