-
hydrogen by a
fluorine atom. The
appropriate anion is
called fluorocitrate.
Fluorocitrate is
formed in two
steps from fluoroacetate.
Fluoroacetate is first...
- Fluoroacetate, in the
citric acid cycle, is
converted to
fluorocitrate by
citrate synthase.
Fluorocitrate competitively inhibits aconitase halting the citric...
- 2-
fluorocitrate. 2-
Fluorocitrate arises by
condensation with
oxaloacetate with
fluoroacetyl coenzyme A,
catalyzed by
citrate synthase.
Fluorocitrate binds...
- from a
precursor which is not
itself toxic, such as the
synthesis of
fluorocitrate from
fluoroacetate or the
synthesis of
methylglyoxal from glycerol....
-
examples include terminally fluorinated fatty acids, fluoroacetone, and 2-
fluorocitrate. An
enzyme that
binds fluorine to
carbon – adenosyl-fluoride synthase...
-
organofluorines include ω-fluoro
fatty acids, fluoroacetone, and 2-
fluorocitrate which are all
believed to be
biosynthesized in
biochemical pathways...
-
because it is not
processable using aconitase in the
Krebs cycle (where
fluorocitrate takes place of
citrate as the substrate). The
enzyme is
inhibited and...
- fluoroacetyl-Coenzyme A. This
compound reacts with
oxaloacetate to form
fluorocitrate,
which is toxic,
being an
alternate substrate for
aconitase (normal...
- a
similar toxicity as that of fluoroacetate,
known to
metabolize to
fluorocitrate to
exert the
toxic effect. 2-Fluoroethanol is
converted by
alcohol dehydrogenase...
-
fluoroacetates are
toxic because they are
converted to
fluorocitrate by
fluoroacetyl coenzyme A.
Fluorocitrate can
inhibit aconitate hydratase,
which is needed...
