-
Alvocidib (INN; also
known as
flavopiridol) is a
flavonoid alkaloid CDK9
kinase inhibitor under clinical development by
Tolero Pharmaceuticals for the...
- HCT116
cells can also
function in xenografts, with docetaxel, 5-FU, and
flavopiridol limiting tumor growth in vitro. The HCT116 cell line was
found to have...
- Cyclin-dependent
kinase inhibitor drugs Drug CDKs
Inhibited Condition or
disease Flavopiridol (alvocidib) 1, 2, 4, 6, 9
Acute Myeloid Leukemia (AML)
Roscovitine (Seliciclib)...
-
benzosuberene (PBS) compounds) has a
stable and
equivalent free
energy to
Flavopiridol, SU9516, and CVT-313 inhibitors. Ligand2
scrutinized as a
selective inhibitor...
- transcription.
Wiley Interdiscip Rev RNA 2012; 3:92-103. Chao SH,
Price DH.
Flavopiridol inactivates P-TEFb and
blocks most RNA
polymerase II
transcription in...
-
benzosuberene (PBS) compounds) has a
stable and
equivalent free
energy to
Flavopiridol, SU9516, and CVT-313 inhibitors. Ligand2
scrutinized as a
selective inhibitor...
- of the
hydroxyl group to form the
chromone (or coumarin)
Alvocidib (
flavopiridol)
Dimefline Flavoxate Allan–Robinson
reaction Baker–Venkataraman rearrangement...
- ;
National Cancer Institute of
Canada Clinical Trials Group (2003). "
Flavopiridol in
Untreated or
Relapsed Mantle-Cell Lymphoma:
Results of a
Phase II...
- for
cyclin degradation, is inhibited,
flavopiridol's effects become reversible. Upon the
removal of
flavopiridol,
cells previously induced to exit mitosis...
-
Ballinger CA,
Thompson LJ,
Subbarao VD,
Dumont JA,
Patterson C (1999). "
Flavopiridol inhibits smooth muscle cell
proliferation in
vitro and
neointimal formation...
