-
roles in
which oxytosis/
ferroptosis can
contribute to the
medical field, such as the
development of
cancer therapies.
Ferroptosis activation plays a regulatory...
- levels. ALOX5-mediated
ferroptosis acts as a cell
death pathway upon
oxidative stress in Huntington's disease.
Inhibitors of
ferroptosis are
protective in...
- Sadovsky, H Bayır, Y Tyurina, R He, V
Kagan "iPLA2G6
Protects Cells against Ferroptosis by
Hydrolyzing the
Lipid Signal of Death, 15-HpETE-PE:
Relevance to Parkinson...
-
disease progression, an iron-dependent form of
regulated cell
death called ferroptosis could be involved.
Products of
lipid peroxidation are also
elevated in...
-
balance of
these enzymes a
central regulator of
ferroptosis.
Chelation of iron also
inhibits ferroptosis,
possibly by
depleting iron from lipoxygenases...
-
Lamprecht MR,
Skouta R,
Zaitsev EM,
Gleason CE, et al. (May 2012). "
Ferroptosis: an iron-dependent form of
nonapoptotic cell death". Cell. 149 (5): 1060–1072...
- et al. (2020). "MESH1 is a
cytosolic NADPH phosphatase that
regulates ferroptosis".
Nature Metabolism. 2 (3): 270–277. bioRxiv 10.1101/325266. doi:10...
-
process of
ferroptosis,
coined the term
ferroptosis,
described its key mechanisms, and
developed the
first chemical probes to
control ferroptosis. In 2014...
-
membrane permeabilization and
ferroptosis in
breast cancer.
While mesenchymal breast cancer cells are
vulnerable to
ferroptosis,
ironomycin and salinomycin...
- were
found to have a
secondary role
protecting against cell
death by
ferroptosis in
cellular models by
limiting the
formation of
toxic lipid peroxides...
