-
farnesyl transferase, Caax
protease and
geranylgeranyl transferase I.
Farnesylation is a type of prenylation, a post-translational
modification of proteins...
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gardens from the
Caribbean and
Central America,
where it originates.
Farnesylation Farnesene Farnesyl pyrophosphate Geranylgeraniol Nerolidol Sell, Charles...
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includes the
discovery of the N-Ras
oncogene , the
identification of
farnesylation of Ras proteins, and the
discovery that Ras
signals through the MAPK/ERK...
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Patterson S,
Sinensky M. In
Vitro ****ay and
characterization of the
farnesylation dependent prelamin A endoprotease. J. Biol. Chem. 1997.272: 5298-5304...
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addition of an
isoprenoid group (e.g.
farnesol and geranylgeraniol)
farnesylation geranylgeranylation glypiation,
glycosylphosphatidylinositol (GPI) anchor...
- Ras mutations) are
sensitive to
FTase inhibitors due to
inhibition of
farnesylation of a
number of
other proteins. Therefore, it is
hoped that FTIs, whilst...
-
farnesol is
added to
prelamin A
using protein farnesyltransferase; this
farnesylation is
important in
targeting lamin to the
nuclear envelope,
where it maintains...
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posttranslational modifications to
become mature lamin A.
These steps include farnesylation of the carboxyl-terminal cysteine,
endoproteolytic release of the terminal...
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Meyer C,
Heinze R,
Kadereit D,
Waldmann H, et al. (November 1999). "
Farnesylation of Ras is
important for the
interaction with
phosphoinositide 3-kinase...
- ISBN 0-7216-2921-0.
Young SG, Meta M, Yang SH, Fong LG (December 2006). "Prelamin A
farnesylation and
progeroid syndromes". J. Biol. Chem. 281 (52): 39741–39745. doi:10...
