-
surface and
reciprocal activation of FXII and PK occurs,
forming FXIIa and PKa.
FXIIa can
initiate the
coagulation cascade by
cleaving and
activating factor...
-
factor XII (
FXIIa).
FXIIa is the
first factor activated in the
contact system,
which leads to the
production of bradykinin. The
inhibition of
FXIIa therefore...
-
spontaneous activation but also as the
major regulator of the
contact system (PK,
FXIIa, and FXIa). C1-inhibitor is the
largest member among the
serpin superfamily...
- (Hageman factor).
Prekallikrein is
converted to
kallikrein and FXII
becomes FXIIa.
FXIIa converts FXI into FXIa.
Factor XIa
activates FIX,
which with its co-factor...
- Arg334, with the
second cleavage liberating the
light chain and
forming β-
FXIIa. The
structure of the FnI-EGF-like
tandem domain of
coagulation factor XII...
- the most
important physiological inhibitor of
plasma kallikrein, fXIa and
fXIIa. C1-INH also
inhibits proteinases of the fibrinolytic, clotting, and kinin...
-
activated into
factor XIa by
factor XIIa (
FXIIa), thrombin, and FXIa itself; due to its
activation by
FXIIa, FXI is a
member of the "contact pathway"...
