- An exon is any part of a gene that will form a part of the
final mature RNA
produced by that gene
after introns have been
removed by RNA splicing. The...
- In
molecular biology, an
exonic splicing enhancer (ESE) is a DNA
sequence motif consisting of 6
bases within an exon that directs, or enhances, accurate...
-
encoded by the genome. In humans, it is
widely believed that ~95% of multi-
exonic genes are
alternatively spliced to
produce functional alternative products...
- An
exonic splicing silencer (ESS) is a
short region (usually 4-18 nucleotides) of an exon and is a cis-regulatory element. A set of 103 hexanucleotides...
-
regions may
serve as
regulatory sequences in the pre-mRNA as
exonic splicing enhancers or
exonic splicing silencers.
Untranslated regions (UTRs) are sections...
-
highlights the
predictive value of
hexamer scores in
detecting alterations of
exonic splicing regulatory elements". Hum. Mutat. 34 (11): 1547–57. doi:10.1002/humu...
- also
potentially translated into
protein isoforms.
Although ~95% of multi-
exonic genes are
thought to be
alternatively spliced, one
study on
noisy splicing...
-
exome sequencing is low—i.e.: the
majority of
neoantigens occur within exonic sequence with
sufficient coverage. However, the vast
majority of mutations...
- is
moved to
another gene. SREs are:
present in exons:
exonic splicing enhancers (ESEs),
exonic splicing silencers (ESSs)
present in introns: intronic...
- loop structures, i.e.
Intronic splicing silencer (ISS),
Exonic splicing enhancer (ESE), and
Exonic splicing silencer (ESSE3).
Solution structure of Intronic...
