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Ergosterol (ergosta-5,7,22-trien-3β-ol) is a
mycosterol found in cell
membranes of
fungi and protozoa,
serving many of the same
functions that cholesterol...
-
demethylase enzyme from
demethylating a
precursor to
ergosterol.
Without this
demethylation step, the
ergosterols are not
incorporated into the
growing fungal...
-
closely resemble their eukaryotic homologs.
Fungal steroids include the
ergosterols,
which are
involved in
maintaining the
integrity of the
fungal cellular...
-
destroying the cell wall of the fungus.
These drugs inhibit the
production of
ergosterol,
which is a
fundamental component of the
fungal cell
membrane and wall...
-
instead bind and
extract ergosterol directly from the
cellular membrane thus
disrupting the many
cellular functions ergosterols perform.
Amphotericin B...
- steroid, specifically, by the
action of
ultraviolet light (UV-B or UV-C) on
ergosterol, a form of
provitamin D2. Like cholecalciferol,
ergocalciferol is inactive...
-
demethylation (CYP51) inhibitor,
specifically inhibiting ergosterol biosynthesis.
Ergosterol is a
critical component of
fungal cell membranes. The Safety...
- medications. It
works by
decreasing the
ability of
fungi to
synthesize ergosterol. It
appears to
result in
fungal cell death.
Terbinafine was discovered...
-
Ergosterol peroxide (5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol) is a
steroid derivative. It has been
isolated from a
variety of fungi, yeast, lichens...
- 33 carbons,
binds well to
ergosterol Nystatin Rimocidin Azole antifungals inhibit the
conversion of
lanosterol to
ergosterol by
inhibiting lanosterol 14α-demethylase...
