- with tubulin, but in
early trials,
epothilones have
better efficacy and
milder adverse effects than taxanes.
Epothilones were
originally identified as metabolites...
- González-Chavarría I,
Burgos V, Iturra-Beiza H,
Ulrich H, Paz C (March 2023). "
Epothilones as
Natural Compounds for
Novel Anticancer Drugs Development". International...
-
Daunorubicin Decitabine Docetaxel Doxifluridine Doxorubicin Epirubicin Epothilone Erlotinib Etoposide Exatecan Fludarabine Fluorouracil Fotemustine Gefitinib...
- has been
applied in a
diastereoselective manner in the
synthesis of
epothilones. 3-isoxazolines are
prepared from 2-isoxazolines via
their N-methylation...
-
chemical structure of the
epoxide glycidol, a
common chemical intermediate.
Epothilones are
naturally occurring epoxides. 3,4-Epoxycyclohexylmethyl-3',4'-epoxycyclohexane...
- N. C. (1998). "Probing the Ring Size of
Epothilones:
Total Synthesis of 14-, 15-, 17-, and 18
Epothilones A".
Angewandte Chemie International Edition...
- "Preclinical
Pharmacology and Structure-Activity
Studies of
Epothilones". In
Mulzer JH (ed.). The
Epothilones: An
Outstanding Family of Anti-Tumor Agents: From...
-
eukaryotic cells. It is
effective against both
fungal and
mammalian cells.
Epothilones -
Compounds that
target microtubule function leading to apoptosis. Some...
-
Pharmacology and Structure-Activity
Studies of
Epothilones". In Mulzer,
Johann H. (ed.). The
Epothilones: An
Outstanding Family of Anti-Tumor Agents: From...
-
cancer medication. Sagopilone, also
known as ZK-EPO,
belongs to the
epothilones,
which are
derived from polyketides.
Sagopilone is a 16-bond macrolide...
