- ketoreductase), an
olefin (via a dehydratase), or a
methylene (via an
enoylreductase).
Termination of the
polyketide scaffold biosynthesis can also vary...
- DH-dehydratase, KS-ketoacyl synthase, KR-ketoreductase, MT-methyltransferase, ER-
enoylreductase, C-condensation, TE-thioesterase. (*)-redundant domain/inactive not...
-
group on a
cysteine side-chain KR:
Ketoreductase DH:
Dehydratase ER:
Enoylreductase MT:
Methyltransferase O- or C- (α or β) SH: PLP-dependent
cysteine lyase...
-
dehydratase domain, and
finally reduction to the
methylene catalyzed by an
enoylreductase domain. Each KS
catalytic cycle results in the net
addition of two carbons...
- the disD gene
encodes an
additional acyl
transferase protein and an
enoylreductase (ER). Notably, the ER
encoded in the disD gene was not
involved in the...
-
domain in module-5, a
ketoreductase domain in module-8, and a KR and an
enoylreductase domain in module-10 is
needed to
synthesize intermediate for isomigrastatin...
- (acyltransferase), ATo (inactive acyltransferase), DH (dehydratase), DHo (inactive dehydratase), MT (methyltransferase), ER (
enoylreductase), KR (ketoreductase)....
-
fatty acid synthesis, ketosynthase, ketoreductase, dehydratase, and
enoylreductase are all used in
sequence to
create a
saturated fatty acid then postsynthetic...
- acyltransferase, D-
docking domain, DH- dehydratase, KS-
ketoacyl synthase, KR- ketoreductase, MT- methyltransferase, ER-
enoylreductase, TE- thioesterase....
-
domains that
contribute to
structural variations are
dehydratase (DH),
enoylreductase (ER), and β-ketoreductase (KR). A
module refers to a set of
these domains...
