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Enediynes are
organic compounds containing two
triple bonds and one
double bond.
Enediynes are most
notable for
their limited use as
antitumor antibiotics...
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Molecules which incorporate enediynes into
these larger ring
structures have been
found to be
extremely cytotoxic.
Enediynes are
present in many complicated...
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chemistry does not
direct biosynthetic divergence between 9- and 10-membered
enediynes". Proc Natl Acad Sci U S A. 107 (25): 11331–5. Bibcode:2010PNAS..10711331H...
- The
Sonogashira reaction is a cross-coupling
reaction used in
organic synthesis to form carbon–carbon bonds. It
employs a
palladium catalyst as well as...
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contains a nine-membered
enediyne that is
responsible for most of the molecule's
biological activity.
Unlike other enediynes, this
molecule contains no...
- Semmelhack's laboratory, he
worked on
organic compounds containing the
enediyne functional group that
model the
activity of the
calicheamicin class of...
-
suffix starts with a
consonant or "y", the
final "-e" remains, e.g. "-
enediyne" (which has the "-ene"
suffix and also the "-yne" suffix, for a compound...
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Examples include:
alkyne trimerisation; the
Bergman cyclization of an
enediyne; the Diels–Alder,
between a
conjugated diene and a
substituted alkene,...
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cyclization converts an
enediyne to a
dehydrobenzene intermediate diradical,
which abstracts hydrogen to aromatize. The
enediyne moiety can be included...
- J; Thorson, JS; Shen, B (Feb 2005). "Antitumor antibiotics: bleomycin,
enediynes, and mitomycin".
Chemical Reviews. 105 (2): 739–58. doi:10.1021/cr030117g...
