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Endothelins are
peptides with
receptors and
effects in many body organs.
Endothelin constricts blood vessels and
raises blood pressure. The endothelins...
- is
proteolytically processed to
release endothelin 1.
Endothelin 1 is one of
three isoforms of
human endothelin.
Preproendothelin is
precursor of the peptide...
- An
endothelin receptor antagonist (ERA) is a drug that
blocks endothelin receptors.
Three main
kinds of ERAs exist: Dual ET
Receptor Antagonists, which...
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There are at
least four
known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of
which are G protein-coupled
receptors whose activation result in elevation...
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Endothelin-3 is a
protein that in
humans is
encoded by the EDN3 gene. The
protein encoded by this gene is a
member of the
endothelin family. Endothelins...
-
Endothelin receptor type A, also
known as ETA, is a
human G protein-coupled receptor.
Endothelin receptor type A has been
shown to
interact with HDAC7A...
-
Endothelin receptor type B, (ET-B) is a
protein that in
humans is
encoded by the
EDNRB gene.
Endothelin receptor type B is a G protein-coupled receptor...
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Endothelin 2 (ET-2) is a
protein encoded by the EDN2 gene in humans. It was
first discovered in 1988 by
Yanagisawa and team and
belongs to a
family of...
- Macitentan, sold
under the
brand name Opsumit, is an
endothelin receptor antagonist developed by
Actelion and
approved for the
treatment of
pulmonary arterial...
- both
endothelin A and
endothelin B receptors.
Aprocitentan was
approved for
medical use in the
United States in
March 2024. It is the
first endothelin receptor...
