- An
enamine is an
unsaturated compound derived by the
condensation of an
aldehyde or
ketone with a
secondary amine.
Enamines are
versatile intermediates...
- The
Stork enamine alkylation involves the
addition of an
enamine to a
Michael acceptor (e.g., an α,β -unsaturated
carbonyl compound) or
another electrophilic...
- pattern. Non-carbon
nucleophiles such as water, alcohols, amines, and
enamines can also
react with an α,β-unsaturated
carbonyl in a 1,4-addition. Some...
-
aldehydes toward nucleophilic addition by
formation of
enamines (e.g. used in the
Stork enamine alkylation):
International Union of Pure and
Applied Chemistry...
-
ammonia or a
primary amine gives an
imine With
secondary amine gives an
enamine With
Grignard and
organolithium reagents to give,
after aqueous workup...
-
colorless liquid. It is
classified as an
enamine.
Primary and
secondary enamines tend to isomerize, but
tertiary enamines are
kinetically stable. One unusual...
- the
modern field of
asymmetric organocatalysis.
Researches on
asymmetric enamine catalysis applied to
important intermediates in
steroids synthesis is due...
- reactions. In 1963, G.
Stork reported the
first enamine alkylation reaction for
ketones -
Stork enamine alkylation reaction. In 1976,
Meyers reported the...
-
titanium tetrachloride. In the
Stork enamine alkylation,
secondary amines form
enamines when
exposed to ketones.
These enamines then
react (possibly enantioselectively)...
- of
proline in the
transition state determine the
reaction outcome. An
enamine is
formed during the
reaction and only one
proline molecule is involved...
