-
Druglikeness is a
qualitative concept used in drug
design for how "
druglike" a
substance is with
respect to
factors like bioavailability. It is estimated...
- five or
simply the rule of five (RO5), is a rule of
thumb to
evaluate druglikeness or
determine if a
chemical compound with a
certain pharmacological or...
- Furthermore,
newly invented pharmacologically active moieties may have poor
druglikeness and may
require chemical modification to
become drug-like
enough to be...
- and
hepatic enzymes. In drug design, drug
candidates may have good
druglikeness but fail on first-p****
metabolism because it is
biochemically selective...
- and
logistic advantages for
physicians and the military.
Pharmacology Druglikeness Lipinski's rule of five
Metabolite Chemogenomics Neurotransmitter Peptidomimetic...
- S2CID 201716327. Gregory, Barber. "A
Molecule Designed By AI
Exhibits '
Druglike' Qualities". Wired.
Archived from the
original on 2020-04-30. Retrieved...
- compounds,
linking potency and
lipophilicity in an
attempt to
estimate druglikeness. For a
given compound LiPE is
defined as the pIC50 (or pEC50) of interest...
-
chemists in pre-clinical drug discovery, for example, in the ****essment of
druglikeness of drug candidates. Likewise, it is used to
calculate lipophilic efficiency...
-
Following his
release from prison, in 2022, a
planned software platform named Druglike controlled by
Shkreli was
announced with a
stated aim of
supporting the...
- "First-Principles
Calculation of the
Intrinsic Aqueous Solubility of
Crystalline Druglike Molecules".
Journal of
Chemical Theory and Com****tion. 8 (9): 3322–3337...
