- (+)-
Discodermolide is a
polyketide natural product found to
stabilize microtubules. (+)-
discodermolide was
isolated by
Gunasekera and his co-workers at...
-
starting blocks for the
synthesis of many
targets including dictyostatin,
discodermolide and spongidepsin. Shin, Youseung; Fournier, Jean-Hugues; ****ui, Yoshikazu;...
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chemists due to its
production of a
potent chemical compound called (+)-
discodermolide,
which has
potential therapeutic applications for
cancer treatment....
- has been emplo**** in many
total syntheses in the literature, such as
discodermolide Evans–Tishchenko
reaction Yang,
Jaemoon (2008). "Diastereoselective...
-
multidrug resistant cell lines.
Discodermolide was
initially found to have
immunosuppressive and
antifungal activities.
Discodermolide is a
polyhydroxylated alketetraene...
-
Kosan Biosciences was
acquired by Bristol-Myers
Squibb for $190M.
Discodermolide is a
recently discovered polyketide natural product found to be a potent...
-
family (HSP90 inhibitors) The
cholesterol lowering agent lovastatin Discodermolide Aflatoxin Usnic acid
Anthracimycin Anthramycin Olivetolic acid (intermediate...
-
under investigation as
possible therapies include the
antitumour agents discodermolide (from the
sponge Discodermia dissoluta),
eleutherobin (from the coral...
-
second methyl group was
integrated by a C-methyl-transferase domain.
Discodermolide Rosenberg, Steven; DeVita,
Vincent T.; ****man,
Samuel (2005). Cancer:...
-
molecular glues took a
significant turn in 1996 with the
discovery that
discodermolide stabilized the ****ociation of
alpha and beta
tubulin monomers, functioning...
