- N,N-
Diisopropylethylamine, or Hünig's base, is an
organic compound that is a
tertiary amine. It is
named after the
German chemist Siegfried Hünig [de]...
-
bases of
moderate strength (pKa of
conjugate acid
around 10-13) N,N-
Diisopropylethylamine (DIPEA, also
called Hünig's Base), pKa = 10.75 1,8-Diazabicycloundec-7-ene...
- from a
carboxylic acid. HATU is used
along with Hünig's base (N,N-
diisopropylethylamine), or
triethylamine to form
amide bonds.
Typically DMF is used as...
-
volatile liquid with a
strong fishy odor
reminiscent of ammonia. Like
diisopropylethylamine (Hünig's base),
triethylamine is
commonly emplo**** in
organic synthesis...
- the
radical species TEMPO.
Another non-nucleophilic base is N,N-
diisopropylethylamine. Its
aqueous pKaH (conjugate acid
dissociation constant, a measure...
-
pyridine complex (SO3•C5H5N) in the
presence of
triethylamine or
diisopropylethylamine as base.
Dichloromethane is
frequently used as a
cosolvent for the...
- MeOH is
methanol solvent; (i‑Pr)2EtN is
catalytic diisopropylethylamine...
- in the
vulcanization of rubber. It is also used to
prepare N,N-
diisopropylethylamine (Hünig's base) by
alkylation with
diethyl sulfate. The
bromide salt...
-
protected is
deprotonated with a non-nucleophilic base such as N,N-
diisopropylethylamine (DIPEA, Hunig's base) in
dichloromethane followed by
addition of...
-
alpha to the
newly formed carbonyl.
Using a
bulkier base, such as
diisopropylethylamine, can
mitigate this side reaction.
Dimethyl sulfide, a byproduct...
