-
Dihydroorotate dehydrogenase (DHODH) is an
enzyme that in
humans is
encoded by the
DHODH gene on
chromosome 16. The
protein encoded by this gene catalyzes...
- 4,5-Dihydroorotic acid is a
derivative of
orotic acid
which serves as an
intermediate in
pyrimidine biosynthesis.
Lacroute F (March 1968). "Regulation...
- arthritis. It is a
pyrimidine synthesis inhibitor that
works by
inhibiting dihydroorotate dehydrogenase.
Rheumatoid arthritis and
psoriatic arthritis are the...
- The
compound is
synthesized in the body via a
mitochondrial enzyme,
dihydroorotate dehydrogenase or a
cytoplasmic enzyme of
pyrimidine synthesis pathway...
- dihydroorotase. The
latter is
converted to
orotate by
dihydroorotate oxidase. The net
reaction is: (S)-
Dihydroorotate + O2 →
Orotate + H2O2
Orotate is covalently...
-
drugs and
infections are
often fatal.
Drugs targeting the
class II
dihydroorotate dehydrogenase (DHODH)
proteins of L. prolificans, Scedosporium, Aspergillus...
-
Dihydroorotate dehydrogenase (fumarate) (EC 1.3.98.1,
dihydroorotate oxidase, pyr4 (gene)) is an
enzyme with
systematic name (S)-
dihydroorotate:fumarate...
-
class 2
dihydroorotate dehydrogenases (DHOQO, EC 1.3.5.2) is an
enzyme with
systematic name (S)-
dihydroorotate:quinone oxidoreductase. This
enzyme catalyses...
- a drug that acts as a
potent and
selective inhibitor of the
enzyme dihydroorotate dehydrogenase. It
blocks synthesis of
pyrimidine based nucleotides in...
-
Dihydroorotase (EC 3.5.2.3,
carbamoylaspartic dehydrase,
dihydroorotate hydrolase) is an
enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic...
