Definition of Dihydroorotate. Meaning of Dihydroorotate. Synonyms of Dihydroorotate

- Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes...
- 4,5-Dihydroorotic acid is a derivative of orotic acid which serves as an intermediate in pyrimidine biosynthesis. Lacroute F (March 1968). "Regulation...
- arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. Rheumatoid arthritis and psoriatic arthritis are the...
- dihydroorotase. The latter is converted to orotate by dihydroorotate oxidase. The net reaction is: (S)-Dihydroorotate + O2 → Orotate + H2O2 Orotate is covalently...
- The compound is synthesized in the body via a mitochondrial enzyme, dihydroorotate dehydrogenase or a cytoplasmic enzyme of pyrimidine synthesis pathway...
- a drug that acts as a potent and selective inhibitor of the enzyme dihydroorotate dehydrogenase. It blocks synthesis of pyrimidine based nucleotides in...
- They cause reversible inhibition of dihydroorotate dehydrogenase (DHODH), an enzyme that catalyses dihydroorotate to orotate. This inhibition in turn...
- Dihydroorotate dehydrogenase (fumarate) (EC 1.3.98.1, dihydroorotate oxidase, pyr4 (gene)) is an enzyme with systematic name (S)-dihydroorotate:fumarate...
- (S)-dihydroorotate + NAD+ ⇌ {\displaystyle \rightleftharpoons } orotate + NADH + H+ Thus, the two substrates of this enzyme are (S)-dihydroorotate and...
- drugs and infections are often fatal. Drugs targeting the class II dihydroorotate dehydrogenase (DHODH) proteins of L. prolificans, Scedosporium, Aspergillus...