-
Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a
folic acid (vitamin B9)
derivative which is
converted to
tetrahydrofolic acid by dihydrofolate...
- tetrahydrofolate, is a
folic acid derivative.
Tetrahydrofolic acid is
produced from
dihydrofolic acid by
dihydrofolate reductase. This
reaction is
inhibited by methotrexate...
-
other diaminopyrimidines such as trimethoprim,
inhibits the
reduction of
dihydrofolic acid to
tetrahydrofolic acid by
bacterial cells.
Hofacre CL,
Fricke JA...
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Dihydrofolate reductase, or DHFR, is an
enzyme that
reduces dihydrofolic acid to
tetrahydrofolic acid,
using NADPH as an
electron donor,
which can be converted...
-
synthetase and
inhibit conversion of PABA and
dihydropteroate diphosphate to
dihydrofolic acid, or dihydrofolate.
Inhibiting the
production of
dihydrofolate intermediate...
-
Trimethoprim binds to
dihydrofolate reductase and
inhibits the
reduction of
dihydrofolic acid (DHF) to
tetrahydrofolic acid (THF). THF is an
essential precursor...
-
biosynthesis of
dihydrofolic acid in many microorganisms. The
enzyme dihydropteroate synthetase converts pteridine and 4-aminobenzoic acid to
dihydrofolic acid in...
- pyrophosphate, dihydropterin-CH2OH-diphosphate) is a pteridine; a
precursor to
dihydrofolic acid. Derrick, J. P (2008). The
structure and
mechanism of 6-hydroxymethyl-7...
-
urinary tract, Shigella, Salmonella, and
Pneumocystis jivoreci infections.
Dihydrofolic acid GHS:
GESTIS 492946 Hevener, Kirk E; Yun, Mi-Kyung; Qi, Jianjun;...
-
dihydrofolate reductase, the
enzyme responsible for the
reduction of
dihydrofolic acid to
tetrahydrofolic acid, but
rather to
defective folate metabolism...
