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Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a
folic acid (vitamin B9)
derivative which is
converted to
tetrahydrofolic acid by dihydrofolate...
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folic acid derivative. In humans,
tetrahydrofolic acid is
produced from
dihydrofolic acid by
dihydrofolate reductase. This
reaction is
inhibited by methotrexate...
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synthetase and
inhibit conversion of PABA and
dihydropteroate diphosphate to
dihydrofolic acid, or dihydrofolate.
Inhibiting the
production of
dihydrofolate intermediate...
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Dihydrofolate reductase, or DHFR, is an
enzyme that
reduces dihydrofolic acid to
tetrahydrofolic acid,
using NADPH as an
electron donor,
which can be converted...
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Trimethoprim binds to
dihydrofolate reductase and
inhibits the
reduction of
dihydrofolic acid (DHF) to
tetrahydrofolic acid (THF). THF is an
essential precursor...
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other diaminopyrimidines such as trimethoprim,
inhibits the
reduction of
dihydrofolic acid to
tetrahydrofolic acid by
bacterial cells.
Hofacre CL,
Fricke JA...
- gram-positive and gram-negative bacteria. It
blocks the
synthesis of
dihydrofolic acid by
inhibiting the
enzyme dihydropteroate synthase. It is a competitive...
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dihydrofolate reductase, the
enzyme responsible for the
reduction of
dihydrofolic acid to
tetrahydrofolic acid, but
rather to
defective folate metabolism...
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biosynthesis of
dihydrofolic acid in many microorganisms. The
enzyme dihydropteroate synthetase converts pteridine and 4-aminobenzoic acid to
dihydrofolic acid in...
- p-aminobenzoic acid (PABA) and
compete with PABA to
block its
conversion to
dihydrofolic acid.
Sulfonamides act on the
schizont stages of the
erythrocytic (a****ual)...
