-
Dihydrofolate reductase, or DHFR, is an
enzyme that
reduces dihydrofolic acid to
tetrahydrofolic acid,
using NADPH as an
electron donor,
which can be...
- (conjugate base
dihydrofolate) (DHF) is a
folic acid (vitamin B9)
derivative which is
converted to
tetrahydrofolic acid by
dihydrofolate reductase. Since...
- A
dihydrofolate reductase inhibitor (DHFR inhibitor) is a
molecule that
inhibits the
function of
dihydrofolate reductase, and is a type of antifolate....
-
Folinic acid is a form of
folic acid that does not
require activation by
dihydrofolate reductase to be
useful to the body.
Folinic acid was
first made in 1945...
-
steps both
catalyzed by the same enzyme,
dihydrofolate reductase.
Folic acid is
first reduced to
dihydrofolate and then to tetrahydrofolate. Each step...
-
Dihydrofolate reductase deficiency (DHFR deficiency) is a rare
inherited disorder of
folate metabolism caused by
defects in the DHFR gene. The disorder...
-
animals but not humans. It
works by
blocking folate metabolism via
dihydrofolate reductase in some bacteria,
preventing creation of
bacterial DNA and...
- that
include two
amine groups on a
pyrimidine ring. They
include many
dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and...
-
substrates and two products. When
enzymes bind
multiple substrates, such as
dihydrofolate reductase (shown right),
enzyme kinetics can also show the sequence...
-
methotrexate for DHFR is
about 1000-fold that of
dihydrofolate. DHFR
catalyses the
conversion of
dihydrofolate to the
active tetrahydrofolate. Tetrahydrofolate...
