- five
amino acids),
forcing scFvs to dimerize. This type is
known as
diabodies.
Diabodies have been
shown to have
dissociation constants up to 40-fold lower...
-
commonly produced.
These are the Fab
recombinant antibodies, scFv and
diabodies. Each of the
formats has a
slightly different potential in applications...
-
targeting component now
include multiple smaller antibody fragments like
diabodies, Fab, scFv, and
bicyclic peptides. The
first generation uses
linking technologies...
- "CD19-/CD3-bispecific
antibody of the BiTE
class is far
superior to
tandem diabody with
respect to
redirected tumor cell lysis".
Molecular Immunology. 44...
- et al. (2004). "A
Single Treatment of Yttrium-90-labeled CHX-A''–C6.5
Diabody Inhibits the
Growth of
Established Human Tumor Xenografts in Immunodeficient...
-
targeting of
immunotherapeutic drugs to the
cancer cell. Anti-CD19/CD16
diabodies have been
shown to
enhance the
natural killer cell
response to B-cell...
-
retrieved 2021-12-08 Holliger, P.; Prospero, T.; Winter, G. (1993-07-15). ""
Diabodies":
small bivalent and
bispecific antibody fragments".
Proceedings of the...
- Von der
Lieth CW,
Matys ER,
Little M (October 1999). "Bispecific
tandem diabody for
tumor therapy with
improved antigen binding and pharmacokinetics"....
- 11850/142158. Holliger, P.; Prospero, T.; Winter, G. (15 July 1993). ""
Diabodies":
small bivalent and
bispecific antibody fragments".
Proceedings of the...
-
molecular weight antibodies and
resulted in the
development of minibodies,
diabodies,
single chain variable fragments (scFv) and
single domain fragments (Fv)...
