-
known as
deubiquitinating peptidases,
deubiquitinating isopeptidases,
deubiquitinases,
ubiquitin proteases,
ubiquitin hydrolases, or
ubiquitin isopeptidases...
-
inflammatory stimuli also
activate NF-κB-induced
expression of the
deubiquitinase A20 (TNFAIP3),
which has been
shown to
intrinsically repair the endothelial...
- Wang DM,
Regmi SC,
Mittal M,
Vogel SM, Schlüter D, et al. (May 2018). "
Deubiquitinase function of A20
maintains and
repairs endothelial barrier after lung...
- OTU
deubiquitinase 5 is a
protein that in
humans is
encoded by the OTUD5 gene. This gene
encodes a
member of the OTU (ovarian tumor) domain-containing...
-
ubiquitin carboxy-terminal
hydrolase (UCH)
domain that
gives BAP1 its
deubiquitinase activity.
Recent studies have
shown that BAP1 and its
fruit fly homolog...
- PMC 6878220. PMID 31085270. Lei H, Wang J, Hu J, Zhu Q, Wu Y (August 2021). "
Deubiquitinases in
hematological malignancies".
Biomarker Research. 9 (1): 66. doi:10...
- proliferation, and
inflammatory response.
Complex I is
negatively regulated by
deubiquitinases such as A20, CYLD, and OTULIN,
which destabilize complex I. Complex...
- for
Western Blot analysis. NEM has also been used as an
inhibitor of
deubiquitinases. N-Ethylmaleimide was used by
Arthur Kornberg and
colleagues to knock...
-
peptidase activity protein binding hydrolase activity thiol-dependent
deubiquitinase ISG15-specific
protease activity cysteine-type
endopeptidase activity...
- NF-κB signaling. Also the
hypomorphic mutations in
deubiquitinase enzyme OTULIN (from OTU
deubiquitinase with
linear linkage specificity),
results in elevated...
