- in the skin
known as
desmogleins.
These proteins form the glue that
keeps skin
cells attached and the skin intact. When
desmogleins are attacked, skin cells...
-
desmosomes that join
cells to one another.
Desmogleins are
targeted in the
autoimmune disease pemphigus.
Desmoglein proteins are a type of cadherin, which...
-
which auto-antibodies
target desmogleins. PV is
caused by
circulating autoantibodies (IgG) that
target Dsg3 (
Desmoglein 3) and
sometimes Dsg1. PV is manifested...
-
Desmoglein-1 is a
protein that in
humans is
encoded by the DSG1 gene.
Desmoglein-1 is
expressed everywhere in the skin epidermis, but
mainly it is expressed...
- via
attachment points called desmosomes. When
autoantibodies attack desmogleins, the
cells become separated from each
other and the
epidermis becomes...
-
junctions between epithelial, myocardial, and
certain other cell types.
Desmogleins and
desmocollins connect extracellularly via
homophilic and heterophilic...
-
pemphigus vulgaris antigen is, like the
genes coding for the
other two
known desmogleins, ****igned to
chromosome 18".
Human Genetics. 89 (3): 347–50. doi:10.1007/bf00220557...
-
desmogleins to link
adjacent cells by
extracellular adhesion.
There are
seven desmosomal cadherins in humans,
three desmocollins and four
desmogleins...
-
cadherin family like
desmocollins and
desmogleins.
Patients with
pemphigus have
antibodies targeting their desmoglein proteins,
triggering the
immune system...
- adhesions, as they both
attach cells to the
extracellular matrix.
Instead of
desmogleins and
desmocollins in the
extracellular space,
hemidesmosomes utilize integrins...
