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Demethylating agents are
chemical substances that can
inhibit methylation,
resulting in the
expression of the
previously hypermethylated silenced genes...
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protein shows high
similarity with the
enzyme AlkB
which oxidatively demethylates DNA. FTO is a
member of the
superfamily of alpha-ketoglutarate-dependent...
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including natural products such as
codeine (O-methylmorphine), have been
demethylated by
heating the
substance in
molten pyridine hydrochloride (melting point...
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concentrations (EC50 > 20 μM); however, [MDA], the main
psychoactive N-
demethylated phase I
metabolite of MDMA,
potently activated the
receptor at submicromolar...
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Sarcosine oxidase is an
enzyme (EC 1.5.3.1) that
catalyzes the
oxidative demethylation of
sarcosine to
yield glycine, H2O2, 5,10-CH2-tetrahydrofolate in...
- it is a derivative.
Norbaeocystin is an N-
demethylated derivative of
baeocystin (itself an N-
demethylated derivative of psilocybin), and a phosphorylated...
-
metabolized by
catechol O-methyltransferase (COMT).
Pseudoephedrine is
demethylated into the
metabolite norpseudoephedrine to a
small extent.
Similarly to...
-
contribute to the
metabolism of
methamphetamine via an
enzyme which N-
demethylates methamphetamine and 4-hydroxymethamphetamine into
amphetamine and 4-hydroxyamphetamine...
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Asendin among others, is a
tricyclic antidepressant (TCA). It is the N-
demethylated metabolite of loxapine.
Amoxapine first received marketing approval in...
-
testosterone derivatives:
dihydrotestosterone (DHT)
derivatives 19-
Demethylated testosterone derivatives: 19-nortestosterone (nandrolone) derivatives...
