-
Dipeptidases are
enzymes secreted by
enterocytes into the
small intestine.
Dipeptidases hydrolyze bound pairs of
amino acids,
called dipeptides. Dipeptidases...
-
Cilastatin inhibits the
human enzyme dehydropeptidase.
Dehydropeptidase is an
enzyme found in the
kidney and is
responsible for
degrading the antibiotic...
-
interfering with the bacteria's cell wall.
Cilastatin blocks the
activity of
dehydropeptidase I
which prevents the
breakdown of imipenem. Imipenem/cilastatin was...
-
mammalian kidney by a
dehydropeptidase enzyme to a
nephrotoxic intermediate, and thus is co-formulated with the
dehydropeptidase inhibitor cilastatin....
-
Membrane dipeptidase (EC 3.4.13.19,
renal dipeptidase,
dehydropeptidase I (DPH I), dipeptidase, aminodipeptidase,
dipeptide hydrolase,
dipeptidyl hydrolase...
-
Stenotrophomonas maltophilia.
Imipenem is
rapidly degraded by the
renal enzyme dehydropeptidase 1 when
administered alone, and is
almost always coadministered with...
-
across the
bacterial outer membrane.
Unlike imipenem, it is
stable to
dehydropeptidase-1, so can be
given without cilastatin. In 2016, a
synthetic peptide-conjugated...
- Imipenem/cilastatin/relebactam
Combination of
Imipenem β-Lactam
antibiotic Cilastatin Dehydropeptidase inhibitor Relebactam β-Lactamase
inhibitor Clinical data
Trade names...
- N-acyl-L-amino acid amidohydrolase.
Other names in
common use
include dehydropeptidase II, histozyme, hippuricase, benzamidase,
acylase I, hippurase, amido...
- required.[citation needed]
Doripenem is
metabolized by the
enzyme dehydropeptidase-I into an
inactive ring-opened metabolite. In
young and
healthy adults...
