- was inhibited,
decatenation was
almost completely blocked. This
suggests that
Topoisomerase IV is the
primary protein for
decatenation of interlinked...
- The
replisome is a
complex molecular machine that
carries out
replication of DNA. The
replisome first unwinds double stranded DNA into two
single strands...
- DNA
supercoil relaxation,
unknotting of single-stranded circles, and
decatenation,
provided at
least one
partner has a single-stranded region. In the case...
- the
genetic studies, HU was
shown to
stimulate DNA gyrase-catalyzed
decatenation of DNA in vitro. It is
unclear mechanistically how HU
modulates the activities...
- identified, however:
Topoisomerase II uses ATP
hydrolysis to
catalyze decatenation of DNA entanglements,
promoting sister chromatid resolution. Condensins...
- DNA
molecules will
remain linked together. This
issue is
handled by
decatenation of the two DNA
molecules by a type II topoisomerase. Type II topoisomerases...
-
supercoils in
nicked and
gapped DNA
drives DNA
unknotting and
postreplicative decatenation".
Nucleic Acids Research. 43 (15): 7229–36. doi:10.1093/nar/gkv683. PMC 4551925...
-
Diffley JF, Aragón L (2011). "Positive
supercoiling of
mitotic DNA
drives decatenation by
topoisomerase II in eukaryotes". Science. 331 (6022): 1328–32. Bibcode:2011Sci...
-
degrades cyclins. The BRCT
domain is
involved in the
regulation of the
decatenation checkpoint at the end of
replication by
binding Topo IIα this arrest...
- Broderick, Ronan; Niedzwiedz,
Wojciech (2015-08-12). "Sister
chromatid decatenation:
bridging the gaps in our knowledge". Cell Cycle. 14 (19): 3040–3044...
