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Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are
chemical compounds that
inhibit histone deacetylases.
Since deacetylation of histones...
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utilization proteins, the
histone deacetylases form an
ancient protein superfamily known as the
histone deacetylase superfamily. HDACs, are classified...
- A
protein deacetylase is any
enzyme that
removes acetyl groups from
lysine amino acids in proteins. The main ones are
histone deacetylases (HDACs) and...
- Sir2 and some, but not all,
sirtuins are
protein deacetylases.
Unlike other known protein deacetylases,
which simply hydrolyze acetyl-lysine residues,...
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Schreiber SL (April 1999). "Three
proteins define a
class of
human histone deacetylases related to
yeast Hda1p".
Proceedings of the
National Academy of Sciences...
- and Leu144. This gene
product belongs to the
histone deacetylase family.
Histone deacetylases act via the
formation of
large multiprotein complexes and...
- NAD+-consuming enzymes, such as CD38, CD157,
PARPs and the NAD-dependent
deacetylases (sirtuins,such as Sir2.).
These enzymes act by
transferring an acetyl...
- t(8;21) in
acute leukemia,
makes distinct contacts with
multiple histone deacetylases and
binds mSin3A
through its
oligomerization domain".
Molecular and Cellular...
-
Schreiber SL (April 1999). "Three
proteins define a
class of
human histone deacetylases related to
yeast Hda1p".
Proceedings of the
National Academy of Sciences...
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modifications by
specific enzymes, e.g.,
histone acetyltransferases (HATs),
deacetylases, methyltransferases, and kinases, and 2) ATP-dependent
chromatin remodeling...
