- A
protein deacetylase is any
enzyme that
removes acetyl groups from
lysine amino acids in proteins. The main ones are
histone deacetylases (HDACs) and...
-
Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are
chemical compounds that
inhibit histone deacetylases.
Since deacetylation of histones...
-
utilization proteins, the
histone deacetylases form an
ancient protein superfamily known as the
histone deacetylase superfamily. HDACs, are classified...
- Sir2 and some, but not all,
sirtuins are
protein deacetylases.
Unlike other known protein deacetylases,
which simply hydrolyze acetyl-lysine residues,...
- and Leu144. This gene
product belongs to the
histone deacetylase family.
Histone deacetylases act via the
formation of
large multiprotein complexes and...
-
Schreiber SL (April 1999). "Three
proteins define a
class of
human histone deacetylases related to
yeast Hda1p".
Proceedings of the
National Academy of Sciences...
-
modulating the
transcriptional activities of
nuclear receptors.
Histone deacetylases can be
regulated by
endogenous factors,
dietary components, synthetic...
- NAD+-consuming enzymes, such as CD38, CD157,
PARPs and the NAD-dependent
deacetylases (sirtuins,such as Sir2.).
These enzymes act by
transferring an acetyl...
- t(8;21) in
acute leukemia,
makes distinct contacts with
multiple histone deacetylases and
binds mSin3A
through its
oligomerization domain".
Molecular and Cellular...
-
Schreiber SL (April 1999). "Three
proteins define a
class of
human histone deacetylases related to
yeast Hda1p".
Proceedings of the
National Academy of Sciences...
