- 5mC
marks are
placed on
genomic DNA via DNA
methyltransferases (
DNMTs).
There are 5
DNMTs in humans: DNMT1, DNMT2, DNMT3A, DNMT3B, and DNMT3L, and in algae...
-
methyltransferases (
DNMTs) such as DNMT1, are
engaged to bind the DNA and to
replicate the
methylation to the
daughter strand,
DNMTs are
bound to decitabine...
- In biochemistry, the DNA
methyltransferase (DNA MTase,
DNMT)
family of
enzymes catalyze the
transfer of a
methyl group to DNA. DNA
methylation serves a...
-
epigenetic regulatory state.
Numerous proteins can
physically interact with
DNMTs themselves,
which help
target DNMT1 to hemi-methylated DNA.
Several new[when...
- re-express
these genes by
inhibiting the
DNMTs. 5-Aza-2'-deoxycytidine (decitabine) is a
nucleoside analog that
inhibits DNMTs by
trapping them in a
covalent complex...
- brain. DNA
cytosine methylation is
catalyzed by DNA
methyltransferases (
DNMTs).
Methylcytosine demethylation is
catalyzed in
several stages by TET enzymes...
-
three isoforms that have a
functional catalytic domain. In general, all
DNMTs require accessory proteins for
their biological function. The PWWP motif...
-
transcription and is
mediated through the
activity of DNA
methyltransferases (
DNMTs). DNMT3A and DNMT3B
regulate de novo
methylation of CpG sites,
while DNMT1...
- in
chromatin can
recruit complexes that
contain DNA
methyltransferases (
DNMTs), a
histone deacetylase (SIRT1), and a
histone methyltransferase (EZH2)...
- brain. DNA
cytosine methylation is
catalyzed by DNA
methyltransferases (
DNMTs).
Methylcytosine demethylation is
catalyzed in
several stages by TET enzymes...
