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Norepinephrine transporter 27,000–30,500 (Ki) 360–405 (IC50) 54–110 (EC50) (rat)
DATTooltip Dopamine transporter 6,500–>10,000 (Ki) 1,440–21,000 (IC50) 51–278 (EC50)...
- v t e
Monoamine reuptake inhibitors DATTooltip Dopamine transporter (DRIsTooltip
Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter (NRIsTooltip...
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Human NETTooltip Norepinephrine transporter 82–291 IC50
Inhibitor Human DATTooltip Dopamine transporter 63 Ki
Inhibitor Rat HCN1Tooltip Hyperpolarization-activated...
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NETTooltip Norepinephrine transporter 5,600–>30,000 (Ki) >100,000 (IC50)
DATTooltip Dopamine transporter >30,000 (Ki) >100,000 (IC50) Notes: The
smaller the...
- v t e
Monoamine reuptake inhibitors DATTooltip Dopamine transporter (DRIsTooltip
Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter (NRIsTooltip...
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transporter 15.2
Human NETTooltip Norepinephrine transporter 1,440
Human DATTooltip Dopamine transporter 1,060
Human 5-HT2A 3,130 Rat 5-HT2C 3,120 Rat H1...
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transporter 3676+ ND
NETTooltip Norepinephrine transporter 10000+ ND
DATTooltip Dopamine transporter 10000+ ND 5-HT1A 2063–2720
Antagonist 5-HT1B 509–660...
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NETTooltip Norepinephrine transporter 13,000 (Ki) 14,000 (IC50) >10,000 (EC50)
DATTooltip Dopamine transporter 6,000–>30,000 (Ki) >100,000 (IC50) >10,000 (EC50)...
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Modafinil activity profile Site
Potency Type
Species Refs
DATTooltip Dopamine transporter 1.8–2.6 μM 4.8 μM 6.4 μM 4.0 μM Ki Ki IC50a IC50a
Human Rat Human...
- v t e
Monoamine reuptake inhibitors DATTooltip Dopamine transporter (DRIsTooltip
Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter (NRIsTooltip...
