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Human NETTooltip Norepinephrine transporter 82–291 IC50
Inhibitor Human DATTooltip Dopamine transporter 63 Ki
Inhibitor Rat HCN1Tooltip Hyperpolarization-activated...
- v t e
Monoamine reuptake inhibitors DATTooltip Dopamine transporter (DRIsTooltip
Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter (NRIsTooltip...
- v t e
Monoamine reuptake inhibitors DATTooltip Dopamine transporter (DRIsTooltip
Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter (NRIsTooltip...
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transporter 0.15–3.3
Human NETTooltip Norepinephrine transporter 420–925
Human DATTooltip Dopamine transporter 22–315
Human 5-HT1A >35,000
Human 5-HT2A 2,207 Rat...
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transporter 15.2
Human NETTooltip Norepinephrine transporter 1,440
Human DATTooltip Dopamine transporter 1,060
Human 5-HT2A 3,130 Rat 5-HT2C 3,120 Rat H1...
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transporter ≥3,676 ND
NETTooltip Norepinephrine transporter >10,000 ND
DATTooltip Dopamine transporter >10,000 ND 5-HT1A 2,063–2,720
Antagonist 5-HT1B 509–660...
- v t e
Monoamine reuptake inhibitors DATTooltip Dopamine transporter (DRIsTooltip
Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter (NRIsTooltip...
- 23–40 401–484 Rat
NETTooltip Norepinephrine transporter ≥240 ≥340 Rat
DATTooltip Dopamine transporter >1,000 >1,000 Rat 5-HT1A >1,000 >1,000 Rat 5-HT1B/1D...
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Modafinil activity profile Site
Potency Type
Species Refs
DATTooltip Dopamine transporter 1.8–2.6 μM 4.8 μM 6.4 μM 4.0 μM Ki Ki IC50a IC50a
Human Rat Human...
- v t e
Monoamine reuptake inhibitors DATTooltip Dopamine transporter (DRIsTooltip
Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter (NRIsTooltip...
