-
enabling the
targeting of
several disease pathways.
DARPins and multi-
DARPins can also be
fused to non-
DARPin elements, such as a toxin, to
generate targeted...
-
depending on the
exact design.
Several mono-
DARPins can be
linked (genetically or chemically) to multi-
DARPins,
which then
combine multiple activities in...
- (roughly 19 kDa in size) by
utilising a
rigid imaging scaffold, and
using DARPins as
modular binding domains between the
scaffold and the
protein of interest...
-
combat COVID-19,
Novartis bought 6% of all
shares outstanding in
Swiss DARPin research company Molecular Partners AG at CHF 23 per share. In December...
-
Ankyrin Repeat Proteins (
DARPins) were
created as a
robust alternative scaffold for
binding proteins (antibody mimetics).
DARPins are
derived from naturally...
-
domain antibody fragments (Nanobodies),
designed ankyrin repeat proteins (
DARPins) and aptamers.
Disease detection at the
molecular level is
driving the...
- as an
entry inhibitor. CD4
specific Designed Ankyrin Repeat Proteins (
DARPins)
potently block viral entry of
diverse strains and are
being developed...
- PMID 16299519. S2CID 84757398.
Stumpp MT, Binz HK,
Amstutz P (August 2008). "
DARPins: a new
generation of
protein therapeutics". Drug Discov. Today. 13 (15–16):...
- Plückthun, A (August 2014). "Engineered
proteins with
desired specificity:
DARPins,
other alternative scaffolds and
bispecific IgGs". Curr Opin
Struct Biol...
-
Intracellular Intrabody Antibody mimetics Affibody molecule Affilin Affimer Affitin Alphabody Anticalin Avimer DARPin Kunitz domain peptide Monobody nanoCLAMP...
