Definition of DARPins. Meaning of DARPins. Synonyms of DARPins

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Definition of DARPins

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Meaning of DARPins from wikipedia

- for four- (N2C) or five- (N3C) repeat DARPins is rather small for a biologic (ca 10% of the size of an IgG). DARPins constitute a new class of potent, specific...
- depending on the exact design. Several mono-DARPins can be linked (genetically or chemically) to multi-DARPins, which then combine multiple activities in...
- Ankyrin Repeat Proteins (DARPins) were created as a robust alternative scaffold for binding proteins (antibody mimetics). DARPins are derived from naturally...
- PMID 16299519. S2CID 84757398. Stumpp MT, Binz HK, Amstutz P (August 2008). "DARPins: a new generation of protein therapeutics". Drug Discov. Today. 13 (15–16):...
- (roughly 19 kDa in size) by utilising a rigid imaging scaffold, and using DARPins as modular binding domains between the scaffold and the protein of interest...
- domain antibody fragments (Nanobodies), designed ankyrin repeat proteins (DARPins) and aptamers. Disease detection at the molecular level is driving the...
- combat COVID-19, Novartis bought 6% of all shares outstanding in Swiss DARPin research company Molecular Partners AG at CHF 23 per share. In December...
- as an entry inhibitor. CD4 specific Designed Ankyrin Repeat Proteins (DARPins) potently block viral entry of diverse strains and are being developed...
- Intracellular Intrabody Antibody mimetics Affibody molecule Affilin Affimer Affitin Alphabody Anticalin Avimer DARPin Kunitz domain peptide Monobody nanoCLAMP...
- Plückthun, A (August 2014). "Engineered proteins with desired specificity: DARPins, other alternative scaffolds and bispecific IgGs". Curr Opin Struct Biol...