-
Cytosine (/ˈsaɪtəˌsiːn, -ˌziːn, -ˌsɪn/) (symbol C or Cyt) is one of the four
nucleotide bases found in DNA and RNA,
along with adenine, guanine, and thymine...
- prokaryotes, even
though the rate of
cytosine DNA
methylation can
differ greatly between species: 14% of
cytosines are
methylated in
Arabidopsis thaliana...
- are read as
cytosines after sequencing represent methylated cytosines,
while those that are read as
thymines represent unmethylated cytosines in the genomic...
- methyltransferases. In mammals, 70% to 80% of CpG
cytosines are methylated.
Methylating the
cytosine within a gene can
change its expression, a mechanism...
- In enzymology, a
cytosine deaminase (EC 3.5.4.1) is an
enzyme that
catalyzes the
chemical reaction cytosine + H2O ⇌ {\displaystyle \rightleftharpoons }...
-
methylated cytosines. Thus,
bisulfite treatment introduces specific changes in the DNA
sequence that
depend on the
methylation status of
individual cytosine residues...
-
Cytosine glycols are
intermediate unstable products of
cytosine oxidation. These, in turn, are
thought to
undergo deamination to
uracil glycol, dehydration...
- and
analyzing naturally-manifested
methylated cytosines in vivo
rather than
chemically methylated cytosines. In 1970, a
breakthrough occurred when it was...
-
adapter oligonucleotides have all
cytosines replaced with 5’methyl-
cytosines to
prevent deamination of
these cytosines in the
bisulfite conversion reaction...
-
eukaryotes methylate only a
small percentage of
these sites, but 70-80% of CpG
cytosines are
methylated in vertebrates. In
mammalian cells,
clusters of CpG at...
