-
alpha helices and a beta-sheet.
Other cyclophilins have
similar structures to
cyclophilin A. The cyclosporin-
cyclophilin A
complex inhibits a calcium/calmodulin-dependent...
- PPIA is an 18 kDa, 165-amino acid long
cytosolic protein. Like
other cyclophilins, PPIA
forms a β-barrel
structure with a
hydrophobic core. This β-barrel...
- eukaryotes,
cyclophilins localize ubiquitously to many cell and
tissue types. In
addition to
PPIase and
protein chaperone activities,
cyclophilins function...
-
identified two
conserved signature indels (CSIs) in
their proteins:
cyclophilin-like
protein and
inner mitochondrial membrane protease ATP23,
which are...
-
proteins that have
prolyl isomerase activity and are
related to the
cyclophilins in function,
though not in
amino acid sequence.
FKBPs have been identified...
- eukaryotes,
cyclophilins localize ubiquitously to many cell and
tissue types. In
addition to
PPIase and
protein chaperone activities,
cyclophilins also function...
-
recombinant cyclophilins A, B, and C
degrade DNA
independently of
peptidylprolyl cis-trans-isomerase activity.
Potential roles of
cyclophilins in apoptosis"...
-
immunosuppressive properties by
inhibiting the peptidyl–prolyl
isomerase activity of
cyclophilin,
ultimately preventing organ transplant rejections. By 1979, CsA was...
-
Sanglifehrin A is a
polyketide natural product found to
potently inhibit cyclophilins and have
immunosuppressive activity.
Isolation and
characterisation of...
-
biochemical characteristics.
These two
families are: "cyclosporin-binding
cyclophilins (CyPs)" and "FK506-binding
proteins (FKBPs)". In 2005, a
group of dual-family...
