-
Cyclophilins (CYPs) are a
family of
proteins named after their ability to bind to
ciclosporin (cyclosporin A), an
immunosuppressant which is
usually used...
-
Peptidylprolyl isomerase A (PPIA), also
known as
cyclophilin A (CypA) or
rotamase A is an
enzyme that in
humans is
encoded by the PPIA gene on chromosome...
-
proteins that have
prolyl isomerase activity and are
related to the
cyclophilins in function,
though not in
amino acid sequence.
FKBPs have been identified...
- the
function of lymphocytes. It does this by
forming a
complex with
cyclophilin to
block the
phosphatase activity of calcineurin,
which in turn decreases...
-
Peptidylprolyl isomerase D (
cyclophilin D), also
known as PPID, is an
enzyme which in
humans is
encoded by the PPID gene on
chromosome 4. As a member...
- as in a few archaebacteria, and thus are
highly conserved. Like
other cyclophilins, PPIB
forms a β-barrel
structure with a
hydrophobic core. This β-barrel...
-
identified two
conserved signature indels (CSIs) in
their proteins:
cyclophilin-like
protein and
inner mitochondrial membrane protease ATP23,
which are...
- conditions, such as
ischemic reperfusion injury, AIDS, and cancer. Like
other cyclophilins, PPIC
forms a β-barrel
structure with a
hydrophobic core. This β-barrel...
-
Rencofilstat (CRV431) is a pan-
cyclophilin inhibitor and
analog of
cyclosporine A
developed for
nonalcoholic steatohepatitis and
hepatocellular carcinoma...
-
immunosuppressive properties by
inhibiting the peptidyl–prolyl
isomerase activity of
cyclophilin,
ultimately preventing organ transplant rejections. By 1979, CsA was...
