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Cyclooxygenase (COX),
officially known as prostaglandin-endoperoxide
synthase (PTGS), is an
enzyme (specifically, a
family of isozymes, EC 1.14.99.1) that...
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Cyclooxygenase-2
inhibitors (COX-2 inhibitors), also
known as coxibs, are a type of
nonsteroidal anti-inflammatory drug (NSAID) that
directly target cyclooxygenase-2...
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Cyclooxygenase-2 (COX-2), also
known as prostaglandin-endoperoxide
synthase 2 (HUGO PTGS2), is an
enzyme that in
humans is
encoded by the PTGS2 gene. In...
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Cyclooxygenase 1 (COX-1), also
known as prostaglandin-endoperoxide
synthase 1 (HUGO PTGS1), is an
enzyme that in
humans is
encoded by the PTGS1 gene. In...
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Cyclooxygenase-3 (COX-3) is an
enzyme that is
encoded by the PTGS1 (COX1) gene, but is not
functional in humans. COX-3 is the
third and most
recently discovered...
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their introduction in 1948.
NSAIDs work by
inhibiting the
activity of
cyclooxygenase enzymes (the COX-1 and COX-2 isoenzymes). In cells,
these enzymes are...
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thromboxanes is due to its
irreversible inactivation of the
cyclooxygenase (COX) enzyme.
Cyclooxygenase is
required for
prostaglandin and
thromboxane synthesis...
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production of
prostaglandins by
decreasing the
activity of the
enzyme cyclooxygenase (COX).
Ibuprofen is a
weaker anti-inflammatory
agent than
other NSAIDs...
- the
third trimester of pregnancy. It
blocks cyclooxygenase-2 (COX-2) more than it
blocks cyclooxygenase-1 (COX-1). It is in the
oxicam family of chemicals...
- part of
pregnancy or
during breastfeeding.
Ketorolac works by
blocking cyclooxygenase 1 and 2 (COX1 and COX2),
thereby decreasing production of prostaglandins...
