-
Coumermycin A1 is an aminocoumarin. Its main
target is the
ATPase site of the DNA
gyrase GyrB subunit.
Chemically induced dimerization Heide L (2009)...
- that
inhibit gyrase are: The
aminocoumarins (including
novobiocin and
Coumermycin A1),
which work by
competitive inhibition of
energy transduction of DNA...
- Actinomycetia.
Other aminocoumarin antibiotics include clorobiocin and
coumermycin A1.
Novobiocin was
first reported in the mid-1950s (then
called streptonivicin)...
-
isolated from soil in
Hokkaido in ****an.
Streptomyces rishiriensis produces coumermycin A1, notomycin, 2-chloroadenosine,
phosphophenylalanarginine and lactonamycin...
-
Perlmutter RM (September 1996). "Activation of the Raf-1
kinase cascade by
coumermycin-induced dimerization". Nature. 383 (6596): 178–81. Bibcode:1996Natur...
-
aminocoumarin antibiotics include: Novobiocin,
Albamycin (Pharmacia And Upjohn)
Coumermycin Clorobiocin The core of
aminocoumarin antibiotics is made up of a 3-amino-4...
- replication:
interactions of
Escherichia coli
gyrase with novobiocin,
coumermycin and
phage DNA-delay gene products".
Journal of
Molecular Biology. 127...
- ****ure.
Aminocoumarins (Fig. 6), such as novobiocin,
clorobiocin and
coumermycin A1, are
natural products from
Streptomyces that
inhibit the
ATPase reaction...
-
coumarin Simocyclioners The
coumarins group,
which includes novobiocin and
coumermycin, are
natural products from the
Streptomyces species and
target the bacterial...
- NSC 128285 35959-87-6 C53H52O22
venicoside E 208707-91-9 C53H55N5O20
coumermycin A2 3130-60-7 C53H56N5O10P 5-hydroxy-dc CEP 197579-70-7 C53H58O17 thielocin...
