- or may
become unresponsive to ****ure
encounters with the antigen. "
Costimulation", The Free Dictionary,
retrieved 2019-07-05 Chen, Lieping; Flies, Dallas...
-
transcriptional and post-translational
alterations in T cells. Specifically, CD28
costimulation controls many
aspects within T cells, one
being the
expression of proinflammatory...
- B7 is a type of
integral membrane protein found on
activated antigen-presenting
cells (APC) that, when
paired with
either a CD28 or CD152 (CTLA-4) surface...
-
Esensten JH,
Helou YA,
Chopra G,
Weiss A,
Bluestone JA (May 2016). "CD28
Costimulation: From
Mechanism to Therapy". Immunity. 44 (5): 973–988. doi:10.1016/j...
-
factors and
their pathways: NFAT, NFkB and AP-1. In
addition and
after costimulation from CD28 the
optimal activation of
expression of IL-2 and
these pathways...
-
Langerhans cells presenting human papillomavirus antigens in the
absence of
costimulation".
Papillomavirus Research (Amsterdam, Netherlands). 2: 21–30. doi:10...
-
either through interfering with the
effect of cytokines,
inhibiting the
costimulation of T cell activation, or
inhibiting B cells.
Cytokines are proinflammatory...
- of CTLA-4,
which is a
molecule crucial in the
regulation of T cell
costimulation,
selectively blocking the
process of T-cell activation. It is intended...
- S,
Rogers PR,
Cheng M, Van
Parijs L,
Croft M (February 2004). "The
costimulation-regulated
duration of PKB
activation controls T cell longevity". Nature...
-
Excessive costimulation and/or
insufficient co-inhibition
leads to the tolerance-breakdown and autoimmunity. CD16a
mediated costimulation provides a...
