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Corticotropic cells, (corticotropes or
corticotrophs) are
basophilic cells in the
anterior pituitary that
produce pro-opiomelanocortin (POMC)
which undergoes...
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precursor polypeptide with 241
amino acid residues. POMC is
synthesized in
corticotrophs of the
anterior pituitary from the 267-amino-acid-long
polypeptide precursor...
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early patterns of cell proliferation. Six w****s into gestation, the
corticotroph cells can be identified. By
seven w****s of gestation, the
anterior pituitary...
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Anterior pituitary produces prolactin, GH, TSH, ACTH, FSH, LH. 15–20% of
corticotroph cells,
produce ACTH. The
targets are the
adrenal glands,
adipocytes and...
- only to
hypercortisolism secondary to
excess production of ACTH from a
corticotroph pituitary adenoma (secondary hypercortisolism/hypercorticism) or due...
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Target Effect Adrenocorticotropic hormone Corticotropin ACTH
Polypeptide Corticotrophs Basophil Adrenal gland Secretion of glucocorticoid, mineralocorticoid...
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various hormone-producing cells,
including Somatotrophs, Lactotrophs,
Corticotrophs, Thyrotrophs, and Gonadotrophs. Rathke's
pouch may
develop benign cysts...
- hypothalamus,
decreasing corticotropin-releasing
hormone (CRH), and
corticotrophs in the
anterior pituitary gland,
decreasing the
amount of adrenocorticotropic...
- Cell name
Relative proportion Hormone produced Hypothalamic regulators Corticotrophs 15% ACTH CRH
Gonadotrophs 10% FSH, LH and hCG* GnRH
Thyrotrophs 5% TSH...
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syndrome is not
understood very well.
Corticotrophinomas are
generated from
corticotroph cells.
Expression of
functional CRH and
vasopressin V3
receptors increase...
