- Mrc1/
claspin. TOPBP1
interacts with and
recruits the
phosphorylated Rad9
component of 9-1-1 and
binds ATR-ATRIP,
which phosphorylates Chk1. Mrc1/
Claspin is...
-
Claspin is a
protein that in
humans is
encoded by the
CLSPN gene.
Xenopus claspin is an
essential upstream regulator of
checkpoint kinase 1 and triggers...
-
polymerase mismatch error, USP20 dis****ociates from HERC2 and
deubiquitinates claspin,
stabilising it to then bind and
activate Chk1. This
allows for DNA replication...
- PMID 18804494. Lin SY, Li K,
Stewart GS,
Elledge SJ (April 2004). "Human
Claspin works with BRCA1 to both
positively and
negatively regulate cell proliferation"...
- are
often necessary.
Regulatory proteins such as
replication protein A,
Claspin, Tim/Tipin, Rad 17, TopBP1 may be
involved to
facilitate Chk1 activation...
-
protein kinase. Parti****tes in S
phase checkpoint arrest by
phosphorylating Claspin NSEOE SPRY2
Protein Sprouty Homolog 2 Two
Hybrid Antagonist of fibroblast...
-
During recovery from DNA
replication and DNA damage, βTrCP
instead targets Claspin in a Plk1-dependent manner. βTrCP has also
emerged as an
important player...
-
During recovery from DNA
replication and DNA damage, βTrCP
instead targets Claspin in a Plk1-dependent manner. βTrCP has also
emerged as an
important player...
- "USP7
counteracts SCFbetaTrCP- but not APCCdh1-mediated
proteolysis of
Claspin". The
Journal of Cell Biology. 184 (1): 13–19. doi:10.1083/jcb.200807137...
- arrest. It acts to
activate Chk1
through a
claspin intermediate which binds the two
proteins together. This
claspin intermediate needs to be phosphorylated...
