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Chordin (from Gr**** χορδή, string, catgut) is a
protein with a
prominent role in dorsal–ventral
patterning during early embryonic development. In humans...
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Chordin-like 1 is a
protein that in
humans is
encoded by the CHRDL1 gene.
Chordin-Like 1 (CHRDL1) is a
structural glycoprotein that sits on the X chromosome...
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binding of
Chordin to BMP-4. Cell 86, 589-598. Piccolo, S., Agius, E., Lu, B., Goodman, S., Dale, L. and De Robertis, E.M. (1997).
Cleavage of
Chordin by the...
- pathways.
Activation of
various secreted factors (Vg1, Nodal, Wnt8C, FGF8 and
Chordin) and
transcription factors (Brachyury and Goosecoid)
adjacent to the site...
- the
protein BMP4
appears to be involved. Two
proteins called Noggin and
Chordin, both
secreted by the mesoderm, are
capable of
inhibiting BMP4 and thereby...
- as the
organizer of the organizer. Even with the BCNE
center (Blastula
chordin and
noggin expression center)
removed from the blastula, the Nieuwkoop...
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decoy receptors, and the
ubiquitination of R-SMADs and receptors. Both
chordin and
noggin are
antagonists of BMPs. They bind BMPs
preventing the binding...
- in the
blastula and
become activated by Wnt
signaling in the
blastula Chordin- and Noggin-expressing (BCNE) center. Sia and Xtwn can
function as homo-...
- non-neural tissue.
Examples of
neural inducers are the
molecules noggin and
chordin. When
embryonic ectodermal cells are
cultured at low
density in the absence...
- streak. In the node proper, the
chordin expression pattern is very
similar to that of HNF-3b, but more rostrally,
chordin is no
longer expressed in the...
