- a much
greater extent. Only
recently have the key
components of the
chemorepulsive pathway been elucidated. The
exact mechanism is
still being investigated...
- a
family of netrin-1 (MIM 601614)
receptors thought to
mediate the
chemorepulsive effect of netrin-1 on
specific axons. For more
information on UNC5 proteins...
- semaphorin, a
molecule that is
chemorepulsive to
growth cones, had
defective pruning in
hippocampal mossy fibers.
Other chemorepulsive molecules include Slits...
-
surrounded by PNNs.
Perineuronal nets have also been
found to
contain chemorepulsive factors, such as semaphorin3A,
which restrict axon
growth necessary...
-
example NRG1 type I and II in the cortex)
while subpallial areas produce chemorepulsive molecules (for
example Slit) to
direct cell migration. Additionally...
- domain. This
secreted Semaphorin-3A
protein can
function as
either a
chemorepulsive agent,
inhibiting axonal outgrowth, or as a
chemoattractive agent, stimulating...
-
Fujisawa H (November 1997). "Neuropilin-semaphorin III/D-mediated
chemorepulsive signals play a
crucial role in
peripheral nerve projection in mice"...
- in C.
elegans revealed a
possible mechanism for
netrin acting as a
chemorepulsive agent (Fig.2). Unc-5, a
transmembrane protein, is
required for dorsal...
- the
growth cone of
spinal neurons is
chemoattractive to netrin-1 yet
chemorepulsive when cAMP is present. Currently, Holt
collaborates with the lab of Giovanni...
